It is human nature to take responses personally, even when it's not personal. The use of the word no tends to evoke feelings of rejection. Especially around phrases like: no, I won't go out with you; no, I don't like the meal you offered; no, I don't want to be your friend; no, I'm not interested in what you're selling. Yes, its understandable to feel disappointed initially by the outcome of the question or, offer that prompted any of the mentioned responses, but its unwise to remain disappointed. It would be short-sighted to not see beyond the initial outcome and focus on the bigger picture.
The greater meaning behind the no could mean various things. It could mean that this person isn't the right one for you to partner with on a relational or business level. Or, that they may not be interested today because your product or service is not the right fit for them. Or better yet, the no could simply be a timing issue and mean - not yet. These are all great outcomes of being told no. It provides immediate clarity and lets you know where you stand with another individual.
The determined person will see this as motivation to continue to persist until they find the Yes. The journey to connecting with the right people takes time and requires a strong level of determination to not be easily swayed by disappointments along the way. The rewards on the other end of that journey, will be worth the challenges you experience before the promise. The bigger question is, are you willing to do what it takes anyway? Do yourself a favor and decide today and everyday to go for no.